ABSTRACT
Under the guide of the medical models, we clearly know the nature of many diseases. However, a lot of complicated diseases, the polygenic and multi-factorial diseases for example, are remained unexplained. Here, we proposed a new medical model, namely the Environment - Genetic - Homeostasis maintenance system (HMS) - Time medical model, which integrated four essential factors (environmental factor, genetic factor, HMS and time factor) of diseases together that can clearly clarify any diseases in form. Here, HMS is referred to the system involved in the maintaining of human homeostasis which is essential to the survival of a person and acts at the level of cell, tissue, organ and human body as a whole. Time factor mainly concerns age of people and duration of diseases. The integrative effects of the three factors decide the health status (disease, pre-disease, or health) of human body. As time goes, the possibility of catching a disease (determined by environments, genetics, and HMS) also dynamically changed. The model can fully explain pathogenesis of all diseases and health, and can be widely used in early diagnosis, treatment, prevention, and many aspects of any diseases. Therefore, it may change the modern medicine at many aspects.